ChloroquineV1, Main, Exploration, bibRecord, 001C03

Chloroquine is therapeutic in murine experimental model of paracoccidioidomycosis

Identifieur interne : 001C03 ( Main/Exploration ); précédent : 001C02; suivant : 001C04

Chloroquine is therapeutic in murine experimental model of paracoccidioidomycosis

Auteurs : Luciane Alarcao Dias-Melicio [Brésil] ; Sueli Aparecida Calvi [Brésil] ; Ana Paula Bordon [Brésil] ; Marjorie A. Golim [Brésil] ; Maria Terezinha Serrao Peracoli [Brésil] ; Angela Maria Victoriano Campos Soares [Brésil]

Source :

FEMS immunology and medical microbiology [ 0928-8244 ] ; 2007.

RBID : Pascal:07-0263607

Descripteurs français

Pascal (Inist)
- Blastomyces brasiliensis, Modèle animal, Fer, Hydrogène Peroxyde, Azote monoxyde, Cytokine, Microbiologie, Immunologie, Chloroquine, Paracoccidioïdomycose, Antiparasitaire, Antipaludique, Antirhumatismal.
Wicri :
- topic : Fer, Immunologie.

English descriptors

KwdEn :
- Animal model, Antimalarial, Antirheumatic agent, Blastomyces brasiliensis, Chloroquine, Cytokine, Hydrogen Peroxides, Immunology, Iron, Microbiology, Nitric oxide, Paracoccidioidomycosis, Parasiticide.

Abstract

Chloroquine, due to its basic properties, has been shown to prevent the release of iron from holotransferrin, thereby interfering with normal iron metabolism in a variety of cell types. We have studied the effects of chloroquine on the evolution of experimental paracoccidioidomycosis by evaluating the viable fungal recovery from lung, liver and spleen from infected mice and H₂O_2, NO production, tumor necrosis factor-alpha (TNF-a), interleukin (IL)-6, IL-10 levels and transferrin receptor (TfR) expression from uninfected and infected peritoneal macrophages. Chloroquine caused a significant decrease in the viable fungal recovery from all organs tested, during all periods of evaluation. Peritoneal macrophages from chloroquine-treated infected mice showed higher H₂O₂ production and TfR expression, and decreased levels of NO, endogenous and stimulated-TNF-α, IL-6 and IL-10 during the three evaluated periods. However, despite its suppressor effects on the macrophage function, the chloroquine therapeutic effect upon murine paracoccidioidomycosis was probably due to its effect on iron metabolism, blocking iron uptake by cells, and consequently restricting iron to fungus growth and survival.

Affiliations:

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Le document en format XML

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<term>Chloroquine</term>
<term>Cytokine</term>
<term>Hydrogen Peroxides</term>
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<term>Azote monoxyde</term>
<term>Cytokine</term>
<term>Microbiologie</term>
<term>Immunologie</term>
<term>Chloroquine</term>
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<term>Antiparasitaire</term>
<term>Antipaludique</term>
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<front><div type="abstract" xml:lang="en">Chloroquine, due to its basic properties, has been shown to prevent the release of iron from holotransferrin, thereby interfering with normal iron metabolism in a variety of cell types. We have studied the effects of chloroquine on the evolution of experimental paracoccidioidomycosis by evaluating the viable fungal recovery from lung, liver and spleen from infected mice and H<sub>2</sub>
O<sub>2,</sub>
 NO production, tumor necrosis factor-alpha (TNF-a), interleukin (IL)-6, IL-10 levels and transferrin receptor (TfR) expression from uninfected and infected peritoneal macrophages. Chloroquine caused a significant decrease in the viable fungal recovery from all organs tested, during all periods of evaluation. Peritoneal macrophages from chloroquine-treated infected mice showed higher H<sub>2</sub>
O<sub>2</sub>
 production and TfR expression, and decreased levels of NO, endogenous and stimulated-TNF-α, IL-6 and IL-10 during the three evaluated periods. However, despite its suppressor effects on the macrophage function, the chloroquine therapeutic effect upon murine paracoccidioidomycosis was probably due to its effect on iron metabolism, blocking iron uptake by cells, and consequently restricting iron to fungus growth and survival.</div>
</front>
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<affiliations><list><country><li>Brésil</li>
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<name sortKey="Bordon, Ana Paula" sort="Bordon, Ana Paula" uniqKey="Bordon A" first="Ana Paula" last="Bordon">Ana Paula Bordon</name>
<name sortKey="Campos Soares, Angela Maria Victoriano" sort="Campos Soares, Angela Maria Victoriano" uniqKey="Campos Soares A" first="Angela Maria Victoriano" last="Campos Soares">Angela Maria Victoriano Campos Soares</name>
<name sortKey="Golim, Marjorie A" sort="Golim, Marjorie A" uniqKey="Golim M" first="Marjorie A." last="Golim">Marjorie A. Golim</name>
<name sortKey="Serrao Peracoli, Maria Terezinha" sort="Serrao Peracoli, Maria Terezinha" uniqKey="Serrao Peracoli M" first="Maria Terezinha" last="Serrao Peracoli">Maria Terezinha Serrao Peracoli</name>
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Chloroquine is therapeutic in murine experimental model of paracoccidioidomycosis

Chloroquine is therapeutic in murine experimental model of paracoccidioidomycosis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri